Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GOT1 | P17174 | 1/20 | 0.36 |
| ▸ | BCKDK | O14874 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102314 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTMAPK1GOT1 | |
| SCHEMBL4837981 | 0.82 | ADORA2A (0.41) | ALDH1A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL31146783 | 0.75 | PDE5A (0.42) | ALDH1A1MAPTGOT1MEN1KMT2A | |
| SCHEMBL3601771 | 0.75 | PDE5A (0.42) | ALDH1A1MAPTGOT1MEN1KMT2A | |
| SCHEMBL31146741 | 0.74 | TDP1 (0.35) | GOT1 | |
| SCHEMBL587805 | 0.74 | TDP1 (0.35) | GOT1 | |
| SCHEMBL29496596 | 0.73 | C1S (0.38) | ALDH1A1KDM4EMAPTMAPK1ACHE | |
| SCHEMBL2459267 | 0.71 | HTT (0.41) | ALDH1A1KDM4EMAPTGOT1ACHE | |
| SCHEMBL29426545 | 0.71 | HTT (0.41) | ALDH1A1KDM4EMAPTGOT1ACHE | |
| SCHEMBL30040888 | 0.71 | LMNA (0.44) | ALDH1A1KDM4EMAPTMAPK1GOT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119233820-A | Azo compounds for the treatment of fibrotic diseases | 乔治-奥古斯特-哥廷根公法基金会大学的大学医学院 | 2024-12-31 | — | — | CN | disclosed |
| WO-2024227701-A1 | PYRIDAZINE COMPOUNDS FOR TREATMENT OF FIBROTIC DISEASES | Tietze Chemical Consulting UG (haftungsbeschränkt) (DE) | 2024-11-07 | — | — | WO | disclosed |
| CN-115417856-A | Pharmaceutical application of substituted heteroaraliphthalazine derivatives and preparation method thereof | 成都奥睿药业有限公司 | 2022-12-02 | — | — | CN | disclosed |