Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.55 |
| ▸ | PARP11 | Q9NR21 | 9/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157851 | 1.00 | PARP10 (0.55) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL29964561 | 0.79 | PARP10 (0.52) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL31079103 | 0.77 | PARP10 (0.55) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL8167365 | 0.77 | PARP11 (0.68) | PARP10PARP11MAPKAPK2GSK3BGRM5 | |
| SCHEMBL29750194 | 0.76 | PARP11 (0.59) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL30040603 | 0.76 | MAPK1 (0.48) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL27157528 | 0.76 | MAPK1 (0.48) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL18123077 | 0.76 | MAPK1 (0.63) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL29914451 | 0.76 | MAPK1 (0.63) | PARP10PARP11MAPK1MAPKAPK2GSK3B | |
| SCHEMBL12077798 | 0.76 | MAPK1 (0.63) | PARP10PARP11MAPK1MAPKAPK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226666-A1 | SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |