Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.68 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.68 |
| ▸ | GRM5 | P41594 | 6/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167149 | 0.82 | PARP10 (0.46) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8154134 | 0.82 | PARP11 (0.68) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8155829 | 0.82 | PARP11 (0.68) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8155722 | 0.81 | PARP11 (1.00) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8155836 | 0.80 | PARP10 (0.76) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8159245 | 0.79 | PARP10 (1.00) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL20294385 | 0.79 | PARP11 (0.72) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL30041002 | 0.77 | PARP10 (0.55) | PARP11PARP10GRM5PARP1F7 | |
| SCHEMBL27157851 | 0.77 | PARP10 (0.55) | PARP11PARP10GRM5PARP1F7 | |
| SCHEMBL29750194 | 0.76 | PARP11 (0.59) | PARP11PARP10PARP1PDPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |