Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539548 | 1.00 | NOTUM (0.57) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL13130237 | 0.81 | L3MBTL1 (0.70) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL12704747 | 0.81 | CHRNB2 (0.53) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL29463424 | 0.79 | CHRNB2 (0.54) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL24660518 | 0.79 | CHRNB2 (0.54) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL23539722 | 0.78 | CHRNB2 (0.53) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL30041989 | 0.78 | CHRNB2 (0.53) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL1545138 | 0.78 | CHRNB2 (0.53) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL2476819 | 0.77 | CLK4 (0.71) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 | |
| SCHEMBL11938358 | 0.76 | CLK4 (0.69) | NOTUMCHRNB2CHRNA5CHRNA4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279741-A | 4-phenyl-N- (phenyl) thiazol-2-amine derivatives and related compounds as Aryl Hydrocarbon Receptor (AHR) agonists for the treatment of, for example, angiogenesis-related disorders or inflammatory disorders | 医肯纳肿瘤学公司 | 2022-11-01 | — | — | CN | disclosed |