Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19739092 | 0.86 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2TP53HPSEKMT2A | |
| SCHEMBL19739081 | 0.85 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2TP53HPSEMAP4K4 | |
| SCHEMBL19739152 | 0.85 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2TP53HPSEKDM4E | |
| SCHEMBL5190823 | 0.84 | KDM4E (0.53) | MAPTSMN1; SMN2TP53HPSEKMT2A | |
| SCHEMBL23999812 | 0.83 | ALDH1A1 (0.62) | MAPTSMN1; SMN2TP53HPSEKMT2A | |
| SCHEMBL19739335 | 0.83 | MMP2 (0.53) | MAPTSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL19739136 | 0.82 | HPSE (0.57) | MAPTSMN1; SMN2TP53HPSEKMT2A | |
| SCHEMBL4576964 | 0.81 | LCK (0.53) | MAPTSMN1; SMN2TP53MAP4K4KMT2A | |
| SCHEMBL30045333 | 0.81 | TP53 (0.47) | MAPTSMN1; SMN2TP53HPSEKMT2A | |
| SCHEMBL20982660 | 0.80 | ALDH1A1 (0.59) | MAPTSMN1; SMN2TP53HPSEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475284-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS INC (US) | 2022-11-02 | — | — | EP | disclosed |