SCHEMBL30056544

SCHEMBL30056544

Brc1ccc(C2CCCC2)cc1.[Ar]

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.48
HDAC6 Q9UBN7 2/20 0.48
HDAC1 Q13547 1/20 0.48
KDM1A O60341 5/20 0.43
KCNH2 Q12809 2/20 0.43
MAOB P27338 2/20 0.43
RCOR1 Q9UKL0 2/20 0.43
KDM1B Q8NB78 1/20 0.43
BRD4 O60885 1/20 0.41
ESR2 Q92731 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NOTUM Q6P988 2/20 0.40
LMNA P02545 1/20 0.40
HTT P42858 1/20 0.40
CYP2A6 P11509 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HAO1 Q9UJM8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3575917 0.97 HDAC8 (0.50) HDAC8HDAC6HDAC1KDM1AKCNH2
SCHEMBL21609716 0.95 HDAC8 (0.48) HDAC8HDAC6HDAC1KDM1AKCNH2
SCHEMBL126116 0.95 HDAC8 (0.48) HDAC8HDAC6HDAC1KDM1AKCNH2
SCHEMBL17061138 0.95 HDAC8 (0.48) HDAC8HDAC6HDAC1KDM1AKCNH2
SCHEMBL233178 0.92 ESR2 (0.47) HDAC8HDAC6HDAC1KDM1AKCNH2
SCHEMBL14804315 0.87 KDM1A (0.48) KDM1AKCNH2MAOBRCOR1KDM1B
SCHEMBL265495 0.87 KDM1A (0.48) KDM1AKCNH2MAOBRCOR1KDM1B
SCHEMBL781509 0.84 HDAC1 (0.54) HDAC8HDAC6HDAC1ESR2NOTUM
SCHEMBL25274751 0.83 HDAC8 (0.41) HDAC8HDAC6HDAC1KDM1AKCNH2
Pyrrolidine SCHEMBL9026279 0.83 CYP2D6 (0.45) HDAC8HDAC6HDAC1KCNH2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4334319-A1 2,8-DIHYDROPYRAZOLO[3,4-B]INDOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER Merck Patent GmbH (DE) 2024-03-13 EP disclosed
EP-4146652-A1 TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS Merck Patent GmbH (DE) 2023-03-15 EP disclosed
WO-2022233442-A1 2,8-DIHYDROPYRAZOLO[3,4-B]INDOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER MERCK PATENT GMBH (DE) 2022-11-10 WO disclosed