Sugi Predict

Sugi Predict / Compounds / SCHEMBL233178

SCHEMBL233178

SCHEMBL233178

Brc1ccc(C2CCC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 8/20 0.47
▸ HDAC1 Q13547 1/20 0.45
▸ HDAC8 Q9BY41 1/20 0.45
▸ HDAC6 Q9UBN7 1/20 0.45
▸ KDM1A O60341 5/20 0.44
▸ KCNH2 Q12809 2/20 0.44
▸ MAOB P27338 2/20 0.44
▸ RCOR1 Q9UKL0 2/20 0.44
▸ KDM1B Q8NB78 1/20 0.44
▸ ESR1 P03372 5/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ BRD4 O60885 1/20 0.42
▸ CYP2A6 P11509 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3575917 0.95 HDAC8 (0.50) ESR2HDAC1HDAC8HDAC6KDM1A
SCHEMBL30056544 0.92 HDAC8 (0.48) ESR2HDAC1HDAC8HDAC6KDM1A
SCHEMBL21609716 0.92 HDAC8 (0.48) ESR2HDAC1HDAC8HDAC6KDM1A
SCHEMBL17061138 0.92 HDAC8 (0.48) ESR2HDAC1HDAC8HDAC6KDM1A
SCHEMBL126116 0.92 HDAC8 (0.48) ESR2HDAC1HDAC8HDAC6KDM1A
SCHEMBL265495 0.89 KDM1A (0.48) ESR2KDM1AKCNH2MAOBRCOR1
SCHEMBL14804315 0.89 KDM1A (0.48) ESR2KDM1AKCNH2MAOBRCOR1
Bicarbonate SCHEMBL7273236 0.89 HDAC8 (0.52) ESR2HDAC1HDAC8HDAC6ESR1
Bicarbonate SCHEMBL7284102 0.89 HDAC8 (0.52) ESR2HDAC1HDAC8HDAC6ESR1
SCHEMBL5886587 0.86 ESR2 (0.56) ESR2HDAC1HDAC8HDAC6ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021078217-A1 TETRACENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF 中国科学院化学研究所 2021-04-29 — — WO claimed
CN-112694388-A Naphthacene derivative and preparation method and application thereof 中国科学院化学研究所 2021-04-23 — — CN claimed
US-20250326765-A1 PDE4B INHIBITOR AND USE THEREOF XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2025-10-23 — — US disclosed
US-20250263426-A1 PDE4B INHIBITOR AND USE THEREOF XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2025-08-21 — — US disclosed
EP-4534540-A1 PDE4B INHIBITOR AND USE THEREOF Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2025-04-09 — — EP disclosed
CN-116217479-B Cannabidiol derivative and preparation method and application thereof 上海中医药大学 2025-03-14 — — CN disclosed
CN-115362151-B Arylpiperidines as monoacylglycerol lipase modulators 詹森药业有限公司 2025-02-11 — — CN disclosed
US-20240294495-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF MONTE ROSA THERAPEUTICS AG (CH) 2024-09-05 — — US disclosed
US-20240092781-A1 ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-03-21 — — US disclosed
US-11912701-B2 Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death HEPAREGENIX GMBH (DE) 2024-02-27 — — US disclosed
US-11912701-B2 Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death HEPAREGENIX GMBH (DE) 2024-02-27 — — US disclosed
CN-1562924-A Full conjugation type monomer of dibenzo cyclobutene and preparation method UNIV SICHUAN (CN) 2005-01-12 — — CN disclosed
US-5264646-A Vinylation, benzocyclobutenes, polysiloxanes THE DOW CHEMICAL COMPANY (US) 1993-11-23 — — US disclosed
US-5243068-A Alkenylation with organic halides THE DOW CHEMICAL COMPANY (US) 1993-09-07 — — US disclosed
US-5196103-A Dielectric polycyclobutarene layer, adhesion, metal carbide interface, sputtering THE DOW CHEMICAL COMPANY (US) 1993-03-23 — — US disclosed
US-5136069-A Reacting with halogenated organic compound in presence of palladium complex catalyst and inorganic hydrogen halide acceptor THE DOW CHEMICAL COMPANY (US) 1992-08-04 — — US disclosed
EP-0323536-A1 Arylcyclobutene/dienophile copolymers THE DOW CHEMICAL COMPANY (US) 1989-07-12 — — EP disclosed
US-4783514-A Polymeric monoarylcyclobutane compositions THE DOW CHEMICAL COMPANY (US) 1988-11-08 — — US disclosed
US-4730030-A Arylcyclobutane/dienophile copolymer THE DOW CHEMICAL COMPANY (US) 1988-03-08 — — US disclosed
US-4724260-A Unsaturated alkyl monoarylcyclobutane monomers THE DOW CHEMICAL COMPANY (US) 1988-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11912701-B2 Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death MAPK4, MAPK7, MAPK14 ESR2 2267/4885HDAC1 828/4885HDAC8 968/4885
US-20240092781-A1 ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, PNLIP ESR2 1608/4885HDAC1 156/4885HDAC8 2079/4885
US-20240294495-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF CRBN, GSPT1, GSPT2 ESR2 1369/4885HDAC1 2790/4885HDAC8 3187/4885
US-20250263426-A1 PDE4B INHIBITOR AND USE THEREOF PDE4B, PDE4A, PDE3B ESR2 2549/4885HDAC1 288/4885HDAC8 710/4885
US-20250326765-A1 PDE4B INHIBITOR AND USE THEREOF PDE4B, PDE4A, PDE3B ESR2 3433/4885HDAC1 270/4885HDAC8 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.