Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDXK | O00764 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325290 | 1.00 | PDXK (0.48) | PDXKMAPTPLAUARKDM4E | |
| SCHEMBL15289010 | 0.80 | PDXK (0.38) | PDXKMAPTPLAUKDM4EALDH1A1 | |
| SCHEMBL9263935 | 0.79 | KMT2A (0.39) | PDXKPLAUALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4920949 | 0.78 | PDXK (0.46) | PDXKMAPTARKDM4EALDH1A1 | |
| SCHEMBL31456630 | 0.78 | PDXK (0.46) | PDXKMAPTARKDM4EALDH1A1 | |
| SCHEMBL1239864 | 0.78 | KDM4E (0.46) | PDXKMAPTPLAUKDM4EALDH1A1 | |
| SCHEMBL1543624 | 0.78 | PDXK (0.46) | PDXKMAPTPLAUARKDM4E | |
| SCHEMBL31395900 | 0.78 | PDXK (0.46) | PDXKMAPTARKDM4EALDH1A1 | |
| SCHEMBL30973615 | 0.78 | PLAU (0.38) | PDXKMAPTPLAULMNARECQL | |
| SCHEMBL15271485 | 0.78 | PLAU (0.38) | PDXKMAPTPLAULMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076460-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |