Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDXK | O00764 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31395900 | 1.00 | PDXK (0.46) | PDXKARKDM4EALDH1A1HPGD | |
| SCHEMBL22564851 | 0.81 | NOS3 (0.39) | ALDH1A1CCR1CCR5CCR8NOS3 | |
| SCHEMBL6953184 | 0.81 | NPSR1 (0.46) | ALDH1A1CCR1CCR5CCR8NOS3 | |
| SCHEMBL23500551 | 0.79 | CCR1 (0.34) | ALDH1A1CCR1CCR5CCR8NOS3 | |
| SCHEMBL30803924 | 0.78 | KDM4E (0.48) | PDXKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30058522 | 0.78 | PDXK (0.48) | PDXKARKDM4EALDH1A1HPGD | |
| SCHEMBL8817708 | 0.78 | KDM4E (0.48) | PDXKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10325290 | 0.78 | PDXK (0.48) | PDXKARKDM4EALDH1A1HPGD | |
| SCHEMBL23534461 | 0.78 | LMNA (0.42) | KDM4EALDH1A1HPGDCCR1CCR5 | |
| SCHEMBL30060571 | 0.78 | LMNA (0.42) | KDM4EALDH1A1HPGDCCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176906-A1 | Substituted Pyrrole Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | US | claimed |
| US-6566528-B1 | Reacting 2-chloro-3-chloromethyl-5-methyl pyridine and 2-nitroimino-1,3-diazacyclopentane in the presence of a base and an organic solvent; insecticides that act at the nicotinic acetylcholine receptor | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-05-20 | — | — | US | claimed |
| EP-1306374-A1 | 1-(2-chloro-5-methyl-3-pyridylmethyl)-2-nitroiminoimadozolidine and a process for the preparation thereof | Council of Scientific and Industrial Research (IN) | 2003-05-02 | — | — | EP | claimed |
| US-20030083350-A1 | 1-(2-CHLORO-5-METHYL-3-PYRIDYLMETHYL)-2-NITROIMINIOMIDAZOLIDINE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-05-01 | — | — | US | claimed |
| US-20250066378-A1 | SPIRO-OXAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2025-02-27 | — | — | US | disclosed |
| US-12162887-B2 | Spiro-oxazolones | HOFFMANN-LA ROCHE INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-20230106150-A1 | SPIRO-OXAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2023-04-06 | — | — | US | disclosed |
| US-11578077-B2 | Spiro-oxazolones | HOFFMANN-LA ROCHE INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-11578077-B2 | Spiro-oxazolones | HOFFMANN-LA ROCHE INC. (US) | 2023-02-14 | — | — | US | disclosed |
| CN-114829362-A | Six-membered and five-membered aromatic ring derivative containing nitrogen heteroatom and used as SHP2 inhibitor | 成都倍特药业股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| WO-2021115286-A1 | SIX-MEMBERED AND FIVE-MEMBERED AROMATIC RING DERIVATIVE CONTAINING NITROGEN HETEROATOMS WHICH CAN BE USED AS SHP2 INHIBITOR | 成都倍特药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| WO-2021115286-A1 | SIX-MEMBERED AND FIVE-MEMBERED AROMATIC RING DERIVATIVE CONTAINING NITROGEN HETEROATOMS WHICH CAN BE USED AS SHP2 INHIBITOR | 成都倍特药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| WO-2015091411-A1 | SPIRO-OXAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015091411-A1 | SPIRO-OXAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| US-20080176906-A1 | Substituted Pyrrole Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | US | disclosed |
| EP-1824841-A1 | SUBSTITUTED PYRROLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006064944-A1 | SUBSTITUTED PYRROLE DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | WO | disclosed |
| US-6566528-B1 | Reacting 2-chloro-3-chloromethyl-5-methyl pyridine and 2-nitroimino-1,3-diazacyclopentane in the presence of a base and an organic solvent; insecticides that act at the nicotinic acetylcholine receptor | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-05-20 | — | — | US | disclosed |
| EP-1306374-A1 | 1-(2-chloro-5-methyl-3-pyridylmethyl)-2-nitroiminoimadozolidine and a process for the preparation thereof | Council of Scientific and Industrial Research (IN) | 2003-05-02 | — | — | EP | disclosed |
| US-20030083350-A1 | 1-(2-CHLORO-5-METHYL-3-PYRIDYLMETHYL)-2-NITROIMINIOMIDAZOLIDINE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162887-B2 | Spiro-oxazolones | AVPR1A, AVPR1B, AVPR2 | PDXK 1617/4885AR 708/4885KDM4E 2174/4885 |
| US-11578077-B2 | Spiro-oxazolones | AVPR1A, AVPR1B, AVPR2 | PDXK 1617/4885AR 708/4885KDM4E 2174/4885 |
| US-20250066378-A1 | SPIRO-OXAZOLONES | AVPR1A, AVPR1B, AVPR2 | PDXK 1617/4885AR 708/4885KDM4E 2174/4885 |
| US-20080176906-A1 | Substituted Pyrrole Derivative | AR, NR5A1, MC2R | PDXK 1831/4885AR 1/4885KDM4E 373/4885 |
| US-20230106150-A1 | SPIRO-OXAZOLONES | AVPR1A, AVPR1B, AVPR2 | PDXK 1617/4885AR 708/4885KDM4E 2174/4885 |
| US-20030083350-A1 | 1-(2-CHLORO-5-METHYL-3-PYRIDYLMETHYL)-2-NITROIMINIOMIDAZOLIDINE AND PROCESS FOR THE PREPARATION THEREOF | CYP1B1, CYP2C9, CYP1A1 | PDXK 303/4885AR 4799/4885KDM4E 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.