Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965925 | 1.00 | TRPM8 (0.60) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| SCHEMBL30965951 | 1.00 | TRPM8 (0.60) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| SCHEMBL22784356 | 1.00 | TRPM8 (0.60) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| SCHEMBL29271787 | 1.00 | TRPM8 (0.60) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| Hydrochloric Acid SCHEMBL30059449 | 0.99 | TRPM8 (0.59) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| Trifluoroacetic Acid SCHEMBL29271817 | 0.93 | TRPM8 (0.60) | TRPM8CHRM3KCNH2 | |
| SCHEMBL29271843 | 0.91 | TRPM8 (0.53) | TRPM8CHRM3KCNH2TRPV1CA12 | |
| SCHEMBL25604564 | 0.89 | HHAT (0.57) | TRPM8CHRM3KCNH2CA12CA1 | |
| SCHEMBL22776130 | 0.88 | TRPM8 (0.61) | TRPM8CHRM3KCNH2TRPV1HHAT | |
| SCHEMBL22776267 | 0.88 | TRPM8 (0.61) | TRPM8CHRM3KCNH2TRPV1HHAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077283-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-10-26 | — | — | EP | disclosed |