Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.30 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.30 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.30 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30934959 | 0.76 | CDC7 (0.37) | TGM2BCHECES1ALDH1A1ALDH2 | |
| SCHEMBL17221433 | 0.73 | GRM5 (0.43) | TGM2BCHECES1ALDH1A1ALDH2 | |
| SCHEMBL14157615 | 0.72 | BCHE (0.34) | BCHECES1ABCC9KCNJ11 | |
| SCHEMBL14992217 | 0.71 | AKR1B1 (0.49) | TGM2MKNK1MKNK2MOGAT2AKR1B1 | |
| SCHEMBL1476086 | 0.71 | TDP2 (0.46) | TGM2MKNK1MKNK2CES1ALDH1A1 | |
| SCHEMBL14991900 | 0.71 | PARP1 (0.42) | TGM2MKNK1MKNK2MOGAT2AKR1B1 | |
| SCHEMBL30029469 | 0.71 | TGM2 (0.46) | TGM2MKNK1MKNK2CES1ALDH1A1 | |
| SCHEMBL17141573 | 0.71 | TGM2 (0.46) | TGM2MKNK1MKNK2CES1ALDH1A1 | |
| SCHEMBL29657028 | 0.71 | PARP1 (0.42) | TGM2MKNK1MKNK2MOGAT2AKR1B1 | |
| SCHEMBL31381594 | 0.69 | CES1 (0.62) | TGM2BCHECES1ALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253252-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS HPK1 INHIBITORS | SILEXON BIOTECH CO., LTD. (CN) | 2022-12-08 | — | — | WO | disclosed |