Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.40 |
| ▸ | PIM1 | P11309 | 6/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060139 | 1.00 | HDAC1 (0.42) | HDAC1HDAC6USP30PIM1FAAH | |
| SCHEMBL30370215 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL27418111 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL24072829 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL27418698 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL24073559 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL25144570 | 0.89 | USP30 (0.42) | HDAC1HDAC6USP30PIM1FAAH | |
| SCHEMBL25144728 | 0.89 | USP30 (0.42) | HDAC1HDAC6USP30PIM1FAAH | |
| SCHEMBL30230922 | 0.88 | HDAC1 (0.43) | HDAC1HDAC6PIM1FAAHMAPT | |
| SCHEMBL30060169 | 0.88 | HDAC1 (0.43) | HDAC1HDAC6PIM1FAAHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132925-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2023-02-15 | — | — | EP | claimed |
| EP-4132925-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2023-02-15 | — | — | EP | disclosed |
| CN-115461340-A | N-cyanopyrrolidines having activity as USP30 inhibitors | 特殊治疗有限公司 | 2022-12-09 | — | — | CN | disclosed |