Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27418698 | 1.00 | HDAC1 (0.49) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL27418111 | 1.00 | HDAC1 (0.49) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL24072829 | 1.00 | HDAC1 (0.49) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL24073559 | 1.00 | HDAC1 (0.49) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL30060139 | 0.89 | HDAC1 (0.42) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL30060110 | 0.89 | HDAC1 (0.42) | HDAC1HDAC6USP30PIM1 | |
| SCHEMBL22557556 | 0.89 | FAAH (0.46) | HDAC1HDAC6USP30 | |
| SCHEMBL24073643 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL25304754 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6USP30CYP2C19CYP1A2 | |
| SCHEMBL25838523 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6USP30CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-B1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | MISSION THERAPEUTICS LTD (GB) | 2024-07-03 | — | — | EP | disclosed |
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |