Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23335067 | 1.00 | MAOA (0.68) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL29933810 | 0.92 | MAOA (0.65) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL18800809 | 0.92 | MAOA (0.65) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL4785737 | 0.91 | MAOA (0.70) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL4785741 | 0.91 | MAOA (0.70) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL24756511 | 0.90 | MAOA (0.68) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL23335044 | 0.90 | MAOA (0.68) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL23335041 | 0.89 | MAOA (0.70) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL24756833 | 0.89 | MAOA (0.67) | MAOAPTPN1ACHEGAAMGAM | |
| SCHEMBL24756241 | 0.89 | MAOA (0.67) | MAOAPTPN1ACHEGAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409892-A1 | METHOD OF DIRECTED DIFFERENTIATION PRODUCING CORNEAL ENDOTHELIAL CELLS, COMPOSITIONS THEREOF, AND USES THEREOF | ASTELLAS INSTITUTE FOR REGENERATIVE MEDICINE (US) | 2024-12-12 | — | — | US | disclosed |
| US-20240368541-A1 | METHODS OF GENERATING MATURE CORNEAL ENDOTHELIAL CELLS | ASTELLAS INSTITUTE FOR REGENERATIVE MEDICINE (US) | 2024-11-07 | — | — | US | disclosed |
| EP-4056573-B1 | USE OF NOVEL COMPOUND, FOR PREVENTING, IMPROVING OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | PRG S&TECH INC (KR) | 2024-11-06 | — | — | EP | disclosed |
| EP-4334437-A1 | METHODS OF GENERATING MATURE CORNEAL ENDOTHELIAL CELLS | Astellas Institute for Regenerative Medicine (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117242173-A | Method for producing mature corneal endothelial cells | 安斯泰来再生医药协会 | 2023-12-15 | — | — | CN | disclosed |
| WO-2022235586-A1 | METHODS OF GENERATING MATURE CORNEAL ENDOTHELIAL CELLS | ASTELLAS INSTITUTE FOR REGENERATIVE MEDICINE (US) | 2022-11-10 | — | — | WO | disclosed |