Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27176347 | 1.00 | HPGDS (0.38) | HPGDSLTA4HCCNCCDK8PIN1 | |
| SCHEMBL315001 | 0.78 | HPGDS (0.44) | HPGDSLTA4HCCNCCDK8PIN1 | |
| SCHEMBL21801560 | 0.78 | HSP90AA1 (0.50) | — | |
| SCHEMBL14031549 | 0.73 | PDPK1 (0.40) | HPGDSLTA4HCCNCCDK8BRD4 | |
| SCHEMBL8929882 | 0.72 | HPGDS (0.40) | HPGDSLTA4HCCNCCDK8PIN1 | |
| SCHEMBL100765 | 0.71 | HPGDS (0.46) | HPGDSLTA4HPIN1BRD4ADRA2A | |
| SCHEMBL3079973 | 0.71 | CYP2D6 (0.39) | HPGDSLTA4HBRD4 | |
| SCHEMBL14535515 | 0.71 | CCR1 (0.54) | HPGDSLTA4HBRD4 | |
| SCHEMBL28714481 | 0.71 | HPGDS (0.39) | HPGDSLTA4HCCNCCDK8PIN1 | |
| SCHEMBL2569188 | 0.69 | RAB9A (0.54) | HPGDSLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368373-B | Spiro compounds and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2025-02-14 | — | — | CN | disclosed |
| WO-2022242767-A1 | SPIRO COMPOUND AND USE THEREOF | 石药集团中奇制药技术（石家庄）有限公司 | 2022-11-24 | — | — | WO | disclosed |
| CN-115368373-A | Spirocyclic compound and use thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2022-11-22 | — | — | CN | disclosed |