Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | DGKA | P23743 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29001314 | 0.94 | HRH2 (0.54) | HRH2HRH1DGKALMNATHRB | |
| SCHEMBL6606038 | 0.92 | HRH2 (0.54) | HRH2HRH1DGKAMAPTMAPK1 | |
| SCHEMBL11712690 | 0.91 | HRH2 (0.60) | HRH2HRH1DGKAALDH1A1 | |
| SCHEMBL11779963 | 0.91 | HRH2 (0.60) | HRH2HRH1DGKAALDH1A1 | |
| Hydrochloric Acid SCHEMBL31722504 | 0.91 | HRH2 (0.53) | HRH2HRH1DGKAMAPTMAPK1 | |
| SCHEMBL11337135 | 0.87 | DGKA (0.57) | HRH2HRH1DGKAMAPTALDH1A1 | |
| SCHEMBL11337142 | 0.87 | DGKA (0.57) | HRH2HRH1DGKAMAPTALDH1A1 | |
| SCHEMBL20057624 | 0.87 | DGKA (0.57) | HRH2HRH1DGKAMAPTALDH1A1 | |
| SCHEMBL3573043 | 0.86 | CYP1A2 (0.46) | HRH2HRH1ALDH1A1MEN1KMT2A | |
| SCHEMBL19034571 | 0.86 | DGKA (0.50) | HRH2HRH1DGKAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334303-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | Nurix Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |