Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3002294 | 0.91 | POLB (0.42) | POLBKDM4EGCKMAPTCYP2C19 | |
| SCHEMBL3003315 | 0.91 | RAB9A (0.35) | KDM4EMAPTCYP2C19CHRNB2CHRNB4 | |
| SCHEMBL3010505 | 0.86 | POLB (0.42) | POLBKDM4EGCKMAPTCYP2C19 | |
| SCHEMBL2999810 | 0.85 | HPGDS (0.45) | GCKRAB9AHTTMEN1NPC1 | |
| SCHEMBL3012028 | 0.81 | RAB9A (0.34) | KDM4EMAPTCYP2C19CHRNB2CHRNB4 | |
| SCHEMBL3010618 | 0.77 | GRM5 (0.39) | KDM4EGCKRAB9ASMN1; SMN2HTT | |
| SCHEMBL3004132 | 0.77 | RAB9A (0.35) | KDM4EMAPTCYP2C19CHRNB2CHRNB4 | |
| SCHEMBL3004293 | 0.76 | HPGDS (0.45) | GCKRAB9AHTTMEN1NPC1 | |
| SCHEMBL3003611 | 0.76 | HPGDS (0.44) | GCKRAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL3013488 | 0.75 | KMT2A (0.40) | KDM4EGCKMAPTCYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-07-29 | — | — | US | claimed |
| EP-2157090-A1 | PYRAZINAMIDE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-02-24 | — | — | EP | claimed |
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-07-29 | — | — | US | disclosed |
| EP-2157090-A1 | PYRAZINAMIDE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | KAT8, GK, KCNJ8 | POLB 2632/4885KDM4E 1952/4885GCK 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.