Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | OXTR | P30559 | 3/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14358203 | 0.76 | NNMT (0.54) | NNMTPOLBTDP1MTNR1AMTNR1B | |
| SCHEMBL3058519 | 0.76 | TDP1 (0.51) | NNMTPOLBTDP1MTNR1AMTNR1B | |
| SCHEMBL31663021 | 0.74 | NPSR1 (0.47) | NNMTPOLBTDP1 | |
| SCHEMBL4257399 | 0.74 | NPSR1 (0.47) | NNMTPOLBTDP1 | |
| SCHEMBL30068228 | 0.73 | CNR2 (0.34) | NNMTPOLBTDP1HDAC4AXL | |
| SCHEMBL21803183 | 0.73 | MTNR1A (0.32) | MTNR1AMTNR1BHDAC4 | |
| SCHEMBL31253850 | 0.72 | NNMT (0.42) | NNMTPOLBTDP1MTNR1AMTNR1B | |
| SCHEMBL2541576 | 0.70 | NNMT (0.36) | NNMTPOLBTDP1PLAU | |
| SCHEMBL2541573 | 0.70 | NNMT (0.36) | NNMTPOLBTDP1PLAU | |
| SCHEMBL2541569 | 0.70 | NNMT (0.36) | NNMTPOLBTDP1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794529-A | POLO-like kinase 4 inhibitors | 欧瑞克制药公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-4337198-A1 | POLO LIKE KINASE 4 INHIBITORS | Oric Pharmaceuticals, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240876-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |