Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19135997 | 1.00 | MEN1 (0.38) | MEN1KMT2ASMN1; SMN2MITFMAPT | |
| SCHEMBL3836840 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL31152344 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL29190922 | 0.79 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2MITFMAPT | |
| SCHEMBL3842407 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3836346 | 0.77 | MAPT (0.55) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL4592987 | 0.76 | GPR3 (0.38) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL9826837 | 0.76 | CYP3A4 (0.41) | ALDH1A1KDM4EGPR3CES1CYP3A4 | |
| SCHEMBL11339200 | 0.76 | GPR3 (0.38) | ALDH1A1KDM4EGPR3CES1CYP3A4 | |
| SCHEMBL1019385 | 0.75 | TDP1 (0.50) | MAPTALDH1A1CYP3A4HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3408271-B1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMA (US) | 2023-01-11 | — | — | EP | disclosed |