Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23668643 | 1.00 | LPL (0.33) | LPLLIPGEGFRMEN1ALDH1A1 | |
| SCHEMBL23569463 | 0.84 | LPL (0.34) | LPLLIPGALDH1A1 | |
| SCHEMBL25173250 | 0.82 | LPL (0.41) | LPLLIPG | |
| SCHEMBL30077847 | 0.82 | LPL (0.41) | LPLLIPG | |
| SCHEMBL21459066 | 0.80 | NQO2 (0.46) | LPLLIPGMEN1ALDH1A1MAPT | |
| SCHEMBL29414003 | 0.80 | NQO2 (0.46) | LPLLIPGMEN1ALDH1A1MAPT | |
| SCHEMBL29964335 | 0.78 | NQO2 (0.41) | LPLLIPGMEN1ALDH1A1MAPT | |
| SCHEMBL24176057 | 0.77 | ESR1 (0.34) | LPLLIPGEGFR | |
| SCHEMBL31270011 | 0.77 | ESR1 (0.34) | LPLLIPGEGFR | |
| SCHEMBL24373694 | 0.75 | MAOA (0.34) | LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415824-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064857-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-04-20 | — | — | WO | disclosed |
| EP-4087843-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2022-11-16 | — | — | EP | disclosed |