Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30079439 | 0.96 | DDB1 (0.43) | HCAR1HPGDDDB1CRBNPRKCG | |
| SCHEMBL30079196 | 0.90 | USP30 (0.42) | HCAR1DDB1CRBNPRKCGPRKCB | |
| SCHEMBL30079289 | 0.80 | DDB1 (0.43) | HCAR1DDB1CRBNPRKCGPRKCB | |
| SCHEMBL2209530 | 0.77 | IDH1 (0.52) | HCAR1DDB1CRBNTP53GPR119 | |
| SCHEMBL1813251 | 0.75 | MAPT (0.49) | HCAR1HPGDDDB1CRBNTP53 | |
| SCHEMBL2604336 | 0.74 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL3963958 | 0.73 | KDM4E (0.44) | HCAR1DDB1CRBNTP53GPR119 | |
| SCHEMBL24895522 | 0.72 | MAPT (0.48) | DDB1CRBNTP53KDM4EMAPT | |
| SCHEMBL5088976 | 0.71 | FPR2 (0.50) | DDB1CRBNTP53KDM4EMAPT | |
| SCHEMBL3256867 | 0.70 | GPR119 (0.48) | HCAR1DDB1CRBNTP53GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |