Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20500436 | 0.84 | CKS1B (0.48) | CKS1BSKP1SKP2CFTRKDM4D | |
| SCHEMBL30897173 | 0.83 | CKS1B (0.46) | CKS1BSKP1SKP2CFTRPIM1 | |
| SCHEMBL30079039 | 0.83 | CKS1B (0.46) | CKS1BSKP1SKP2CFTRKDM4D | |
| SCHEMBL23658236 | 0.78 | CKS1B (0.46) | CKS1BSKP1SKP2CFTRKDM4D | |
| SCHEMBL27142615 | 0.78 | PIM1 (0.47) | CKS1BSKP1SKP2KDM4DPIM1 | |
| SCHEMBL30897138 | 0.77 | CKS1B (0.48) | CKS1BSKP1SKP2CFTRKDM4D | |
| SCHEMBL6222947 | 0.77 | PIM1 (0.59) | CKS1BSKP1SKP2PIM1PIM3 | |
| SCHEMBL20500390 | 0.77 | CKS1B (0.50) | CKS1BSKP1SKP2CFTRPIM1 | |
| SCHEMBL20500373 | 0.76 | CKS1B (0.49) | CKS1BSKP1SKP2CFTRPIM1 | |
| SCHEMBL30078465 | 0.76 | CKS1B (0.49) | CKS1BSKP1SKP2CFTRPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |