SCHEMBL300808

SCHEMBL300808

O=C(CCCCCC1(c2ccccc2)C(=O)NC(=O)NC1=O)NCCOCCOCCNC(=O)c1ccc(C(=O)O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.47
MMP2 P08253 4/20 0.46
MMP9 P14780 4/20 0.46
MMP3 P08254 2/20 0.46
MMP8 P22894 2/20 0.44
MMP13 P45452 2/20 0.44
HDAC1 Q13547 5/20 0.41
HDAC2 Q92769 5/20 0.41
HDAC5 Q9UQL6 5/20 0.41
KDM1A O60341 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
HDAC6 Q9UBN7 10/20 0.41
HDAC3 O15379 4/20 0.41
HDAC4 P56524 4/20 0.41
HDAC7 Q8WUI4 4/20 0.41
HDAC10 Q969S8 4/20 0.41
HDAC11 Q96DB2 4/20 0.41
HDAC8 Q9BY41 4/20 0.41
HDAC9 Q9UKV0 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL271378 0.91 MMP2 (0.54) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL271155 0.89 SMN1; SMN2 (0.44) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL265660 0.86 MMP2 (0.41) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL300807 0.86 MMP2 (0.49) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL12457434 0.84 MMP2 (0.47) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL265249 0.83 MMP2 (0.40) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL12457026 0.83 MMP2 (0.40) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL370702 0.82 MMP2 (0.45) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL12456519 0.81 MMP2 (0.43) SMN1; SMN2MMP2MMP9MMP3MMP8
SCHEMBL300244 0.81 MEN1 (0.52) SMN1; SMN2MMP2MMP9MMP3MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8133743-B2 Phenobarbital derivatives useful in immunoassay ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2012-03-13 US disclosed