Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.39 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083485 | 0.89 | KDM4E (0.47) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL30872083 | 0.88 | KCNN3 (0.49) | RAB9ANPC1KMT2ACDK2CCNE1 | |
| SCHEMBL30872090 | 0.83 | KCNN3 (0.38) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL30872099 | 0.82 | KCNN3 (0.39) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL24792833 | 0.82 | CDK2 (0.57) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL23530939 | 0.82 | KDM4E (0.38) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL30083401 | 0.82 | GSK3B (0.45) | RAB9ANPC1KMT2ACDK2CCNE1 | |
| SCHEMBL30083523 | 0.79 | KCNN3 (0.44) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL30083382 | 0.79 | GPR39 (0.48) | KDM4EMAPTRAB9ANPC1KMT2A | |
| SCHEMBL24792804 | 0.78 | CDK7 (0.60) | KDM4EMAPTRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |