Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089100 | 0.86 | JAK3 (0.44) | GFERTDP1RAB9A | |
| SCHEMBL29136118 | 0.81 | ALDH1A1 (0.53) | GFERALDH1A1RAB9ANPC1 | |
| SCHEMBL23292267 | 0.80 | CYP3A4 (0.55) | HRH1HRH2HRH3 | |
| SCHEMBL7492247 | 0.80 | ALDH1A1 (0.47) | HRH1HRH2TDP1KDM4EALDH1A1 | |
| SCHEMBL30089101 | 0.80 | KDM4E (0.46) | GFERKDM4EALDH1A1 | |
| SCHEMBL18613893 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1 | |
| SCHEMBL27177281 | 0.79 | DPP4 (0.48) | GFERCCR2 | |
| SCHEMBL29136093 | 0.79 | DPP4 (0.48) | GFERCCR2 | |
| SCHEMBL30089092 | 0.79 | SMN1; SMN2 (0.46) | GFERKDM4E | |
| SCHEMBL2636995 | 0.79 | HRH2 (0.41) | HRH1HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4341252-A1 | OXOINDOLINE COMPOUND FOR THE TREATMENT OF INFLAMMATORY DISEASES OR CANCER | F. Hoffmann-La Roche AG (CH) | 2024-03-27 | — | — | EP | disclosed |
| WO-2022243346-A1 | OXOINDOLINE COMPOUND FOR THE TREATMENT OF INFLAMMATORY DISEASES OR CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2022-11-24 | — | — | WO | disclosed |