SCHEMBL30089458

SCHEMBL30089458

COc1cc(N(C(=O)O)C(C)(C)C)ncc1C1CCC(F)(F)CC1.COc1cc(N)ncc1C1CCC(F)(F)CC1

nearest known ligand 0.45

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 20/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23612060 0.82 TRPC6 (0.51) TRPC6
SCHEMBL23612087 0.74 TRPC6 (0.46) TRPC6
SCHEMBL23612044 0.71 GCK (0.45) TRPC6
SCHEMBL23612054 0.71 TRPC6 (0.46) TRPC6
SCHEMBL30021227 0.71 TRPC6 (0.46) TRPC6
SCHEMBL28935526 0.71 TRPC6 (0.41) TRPC6
Trifluoroacetic Acid SCHEMBL21274588 0.70 TRPC6 (0.49) TRPC6
SCHEMBL23612013 0.70 TRPC6 (0.43) TRPC6
SCHEMBL23625784 0.69 GCK (0.41) TRPC6
SCHEMBL30020826 0.69 GCK (0.41) TRPC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4085061-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM Due, Inc. (US) 2022-11-09 EP disclosed