Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301230 | 1.00 | KDM4E (0.56) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL27988321 | 1.00 | KDM4E (0.56) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL27960617 | 0.84 | CSNK2A1 (0.56) | KDM4EHPGDALDH1A1GAAHSD17B10 | |
| SCHEMBL27960609 | 0.84 | CSNK2A1 (0.56) | KDM4EHPGDALDH1A1GAAHSD17B10 | |
| SCHEMBL28298239 | 0.82 | MAPT (0.38) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL28298243 | 0.82 | MAPT (0.38) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL28299546 | 0.82 | MAPT (0.38) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL300882 | 0.79 | LMNA (0.69) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL300897 | 0.79 | KDM4E (0.57) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL300898 | 0.79 | KDM4E (0.57) | KDM4EHPGDALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |