Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 known ✓ | P00519 | 20/20 | 0.66 |
| ▸ | BCR known ✓ | P11274 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28902246 | 1.00 | ABL1 (0.66) | ABL1KCNH2BCRCRBN | |
| SCHEMBL22711583 | 0.96 | ABL1 (0.70) | ABL1KCNH2BCRCRBN | |
| SCHEMBL21477626 | 0.96 | ABL1 (0.70) | ABL1KCNH2BCRCRBN | |
| Hydrochloric Acid SCHEMBL30091086 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| Bromide SCHEMBL30091102 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| Bromide SCHEMBL28902248 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| Hydrochloric Acid SCHEMBL28902254 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| Bromide SCHEMBL28902250 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| Hydrochloric Acid SCHEMBL28902253 | 0.95 | ABL1 (0.69) | ABL1KCNH2BCRCRBN | |
| SCHEMBL23929298 | 0.94 | ABL1 (0.62) | ABL1KCNH2BCRCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304171-A | Solid forms of pyrazine substituted nicotinamide, preparation and use thereof | 深圳市塔吉瑞生物医药有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-115413277-B | Solid forms of pyrazine substituted nicotinamide, preparation and use thereof | 深圳市塔吉瑞生物医药有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-115413277-A | Solid forms of pyrazine-substituted nicotinamide, their preparation and use | 深圳市塔吉瑞生物医药有限公司 | 2022-11-29 | — | — | CN | disclosed |