Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16372354 | 1.00 | LCK (0.46) | LCKMAPK1CA12CA1CA2 | |
| SCHEMBL30405765 | 0.83 | NOTUM (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL17144343 | 0.83 | NOTUM (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL31500498 | 0.81 | SMN1; SMN2 (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL2255434 | 0.81 | SMN1; SMN2 (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL1615811 | 0.81 | NPC1 (0.46) | MAPK1CA12CA1CA2CA7 | |
| SCHEMBL7236303 | 0.80 | CTSA (0.48) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL2593348 | 0.80 | PTPN1 (0.50) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL30390714 | 0.80 | MAPT (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 | |
| SCHEMBL14151888 | 0.80 | MAPT (0.46) | MAPK1CYP1A2TP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058149-A1 | MCL1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-09-21 | — | — | EP | disclosed |