Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174903 | 1.00 | PDE2A (0.46) | PDE2AGAACHRM3PDE4APDE4B | |
| SCHEMBL29174993 | 0.83 | PDE2A (0.36) | PDE2ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL29174941 | 0.82 | PDE10A (0.47) | PDE2AGAACHRM3PDE4APDE4B | |
| SCHEMBL30095656 | 0.82 | PDE10A (0.47) | PDE2AGAACHRM3PDE4APDE4B | |
| SCHEMBL31391497 | 0.82 | PDE2A (0.46) | PDE2ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL25746321 | 0.82 | PDE2A (0.46) | PDE2ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL30748224 | 0.80 | MAT2A (0.41) | PDE4BKMT2AMEN1PDE8BSMN1; SMN2 | |
| SCHEMBL29174824 | 0.80 | KDM4E (0.52) | KMT2APDE8BRAB9AKDM4EPIK3CA | |
| SCHEMBL29174825 | 0.80 | MAT2A (0.41) | PDE4BKMT2AMEN1PDE8BSMN1; SMN2 | |
| SCHEMBL30095689 | 0.80 | KDM4E (0.52) | KMT2APDE8BRAB9AKDM4EPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117529315-A | Imidazole-containing ALK2 kinase inhibitors | 生物水晶制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |