Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ESRRA | P11474 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31126904 | 0.85 | KMT2A (0.53) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL9938759 | 0.84 | TP53 (0.49) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL30096071 | 0.82 | ALDH1A1 (0.48) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL2970855 | 0.77 | MEN1 (0.54) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL3861586 | 0.75 | CYP2D6 (0.60) | KMT2AMEN1TP53CYP3A4CYP2D6 | |
| SCHEMBL5322402 | 0.74 | MEN1 (0.84) | KMT2AMEN1TP53CYP3A4CYP2D6 | |
| SCHEMBL22919766 | 0.74 | KMT2A (0.58) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL21799999 | 0.74 | MEN1 (0.54) | HDAC6KMT2AMEN1TP53CYP3A4 | |
| SCHEMBL20535887 | 0.74 | HDAC6 (1.00) | HDAC6KMT2AMEN1RECQLHDAC3 | |
| SCHEMBL23023127 | 0.73 | NPC1 (0.48) | KMT2ANPC1RAB9AEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115869428-A | HDAC6 inhibitors and imaging agents | 通用医疗公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-110770206-B | HDAC6 inhibitors | 通用医疗公司 | 2022-11-25 | — | — | CN | disclosed |