Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440436 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL2266978 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL15564817 | 0.81 | NQO2 (0.61) | KDM4EALDH1A1HPGDHSD17B10ATM | |
| SCHEMBL30099717 | 0.79 | ATM (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL20680340 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL25269828 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL23579635 | 0.79 | ATM (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL21957297 | 0.78 | AR (0.50) | ATM | |
| SCHEMBL29889991 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL11836043 | 0.77 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115103841-B | Substituted quinolinone piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |