Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23579635 | 1.00 | ATM (0.45) | ATMGRM4KDM4ENQO2THRB | |
| SCHEMBL829894 | 0.81 | KDM4E (0.47) | KDM4ENQO2MEN1KMT2AALDH1A1 | |
| SCHEMBL15564817 | 0.81 | NQO2 (0.61) | ATMKDM4ENQO2MEN1HCRTR1 | |
| SCHEMBL13440436 | 0.79 | KDM4E (0.50) | ATMGRM4KDM4ENQO2THRB | |
| SCHEMBL25269604 | 0.79 | KDM4E (0.42) | KDM4ENQO2THRBALDH1A1RXFP1 | |
| SCHEMBL30099642 | 0.79 | KDM4E (0.50) | ATMGRM4KDM4ENQO2THRB | |
| SCHEMBL21957297 | 0.78 | AR (0.50) | ATM | |
| SCHEMBL829534 | 0.77 | MAPT (0.53) | KDM4ENQO2MEN1KMT2AALDH1A1 | |
| SCHEMBL29891972 | 0.77 | KDM4E (0.65) | ATMKDM4ENQO2KMT2AALDH1A1 | |
| SCHEMBL829976 | 0.77 | KDM4E (0.65) | ATMKDM4ENQO2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115103841-B | Substituted quinolinone piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2024-12-27 | — | — | CN | disclosed |
| EP-4081513-B1 | SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2024-11-20 | — | — | EP | disclosed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |