Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | NQO2 | P16083 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829976 | 1.00 | KDM4E (0.65) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL30727441 | 0.79 | MAT2A (0.50) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL436564 | 0.78 | KDM4E (1.00) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL829894 | 0.78 | KDM4E (0.47) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL9207881 | 0.78 | ALDH1A1 (0.56) | KDM4EHSD17B10HPGDLMNAMAPT | |
| SCHEMBL835247 | 0.77 | KDM4E (0.51) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL30557144 | 0.77 | KDM4E (0.65) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL835056 | 0.77 | KDM4E (0.65) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL21831728 | 0.77 | KDM4E (0.65) | KDM4ENQO2HSD17B10HPGDLMNA | |
| SCHEMBL11823319 | 0.77 | KDM4E (0.65) | KDM4ENQO2HSD17B10HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119564686-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119523983-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119424429-A | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-115103841-B | Substituted quinolinone piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-115003665-B | DGK alpha inhibitors as immune activation substituted aminoquinolones of (2) | 拜耳公司 | 2024-11-08 | — | — | CN | disclosed |
| EP-4065574-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2022-10-05 | — | — | EP | disclosed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-115003665-A | Substituted aminoquinolones as immunoactive DGK alpha inhibitors | 拜耳公司 | 2022-09-02 | — | — | CN | disclosed |