Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SLC13A5 | Q86YT5 | 15/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28587369 | 0.82 | ALDH1A1 (0.56) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL27897976 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| SCHEMBL311565 | 0.77 | PARP1 (0.46) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Citric Acid SCHEMBL27663575 | 0.77 | CYP3A4 (0.57) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL27790507 | 0.77 | ALDH1A1 (0.42) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL28104431 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL27498577 | 0.75 | CYP3A4 (0.59) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL2237856 | 0.74 | ALDH1A1 (0.60) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL5874613 | 0.74 | ALDH1A1 (0.46) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL31082127 | 0.73 | ALDH1A1 (0.48) | ALDH1A1SLC13A5KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115554254-A | Mosapride citrate orally disintegrating tablet and preparation method thereof | 山东新时代药业有限公司 | 2023-01-03 | — | — | CN | disclosed |