Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28276517 | 0.81 | KDM4E (0.58) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28012682 | 0.80 | KDM4E (0.57) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4216096 | 0.78 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4221803 | 0.76 | MEN1 (0.67) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL17420314 | 0.76 | KDM4E (0.52) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4221624 | 0.75 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL20784267 | 0.75 | HTR3A (0.69) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL30103304 | 0.74 | KDM4E (0.58) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1978855 | 0.74 | KDM4E (0.54) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL521324 | 0.73 | MAPT (0.58) | KDM4EGAAKMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271676-A1 | INDOLE-SUBSTITUTED QUINOLINES AND THEIR COMBINATION WITH PLK1 INHIBITORS FOR THE TREATMENT OF CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-12-29 | — | — | WO | disclosed |