Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30030462 | 0.86 | TNKS (0.50) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL23705480 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNATACR3ALDH1A1CYP1A2 | |
| SCHEMBL4454372 | 0.81 | TNKS (0.53) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL12068804 | 0.79 | TNKS (0.49) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL30103173 | 0.76 | AAK1 (0.59) | TNKSTNKS2SMN1; SMN2LMNAHTT | |
| SCHEMBL23508126 | 0.74 | AAK1 (0.49) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL14289622 | 0.73 | POLB (0.50) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL23508272 | 0.73 | TNKS (0.46) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL27185875 | 0.73 | TNKS (0.48) | TNKSTNKS2SMN1; SMN2LMNAPLAU | |
| SCHEMBL23732126 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPTITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230121497-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-04-20 | — | — | US | disclosed |
| EP-4096668-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230121497-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | TNKS 2505/4885TNKS2 1626/4885SMN1; SMN2 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.