Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30030462 | 0.83 | TNKS (0.50) | TNKSTNKS2NAMPTLMNASMN1; SMN2 | |
| SCHEMBL13465239 | 0.82 | HCAR2 (0.49) | TNKSTNKS2NAMPTLMNASMN1; SMN2 | |
| SCHEMBL30103078 | 0.81 | TNKS (0.51) | TNKSTNKS2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5879697 | 0.81 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL1872957 | 0.80 | HCAR2 (0.69) | TNKSTNKS2 | |
| SCHEMBL7331804 | 0.78 | L3MBTL1 (0.40) | LMNASMN1; SMN2POLBTDP1HTT | |
| SCHEMBL13167384 | 0.77 | HTT (0.48) | LMNASMN1; SMN2POLBMAPTHTT | |
| SCHEMBL27185875 | 0.77 | TNKS (0.48) | TNKSTNKS2LMNASMN1; SMN2KCNA5 | |
| SCHEMBL7416209 | 0.76 | LMNA (0.50) | TNKSTNKS2NAMPTLMNASMN1; SMN2 | |
| SCHEMBL23508126 | 0.76 | AAK1 (0.49) | TNKSTNKS2LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | claimed |
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | UNIVERSITY OF WASHINGTON (US) | 2021-02-09 | — | — | US | disclosed |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | UNIVERSITY OF WASHINGTON (US) | 2021-02-09 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
| EP-1960417-B1 | POLYMORPHS OF ANDROGEN RECEPTOR MODULATOR - (N-3H-IMIDAZO [4 , 5-B] PYRIDIN-2-YL-METHYL) -2-FLUORO-4-METHYL-3-OXO-4-AZA-ANDROST- 1-EN-17 . BETA . -CARBOXAMIDE | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20090048283-A1 | Salt of an androgen receptor modulator | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| US-7365202-B2 | Polymorphs of an androgen receptor modulator | MERCK & CO., INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20070129548-A1 | Polymorphs of an androgen receptor modulator | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129548-A1 | Polymorphs of an androgen receptor modulator | SHBG, AR, BRCA1 | TNKS 1457/4885TNKS2 1735/4885NAMPT 4001/4885 |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | AARS1, MTR, GARS1 | TNKS 1107/4885TNKS2 937/4885NAMPT 930/4885 |
| US-20090048283-A1 | Salt of an androgen receptor modulator | AR, SHBG, FSHR | TNKS 1808/4885TNKS2 2258/4885NAMPT 3080/4885 |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | AARS1, MTR, GARS1 | TNKS 1107/4885TNKS2 937/4885NAMPT 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.