Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | IL1B | P01584 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106906 | 0.92 | IDH1 (0.35) | IDH1CRHR1P2RX7IL1BLRRK2 | |
| SCHEMBL30106878 | 0.83 | IDH1 (0.34) | IDH1CRHR1P2RX7IL1BLRRK2 | |
| SCHEMBL30106944 | 0.83 | CRHR1 (0.36) | CRHR1LRRK2GRM2 | |
| SCHEMBL30106936 | 0.82 | IDH1 (0.33) | IDH1P2RX7IL1BLRRK2GRM2 | |
| SCHEMBL30106892 | 0.81 | IDH1 (0.33) | IDH1P2RX7IL1BGRM2BRD4 | |
| SCHEMBL30106951 | 0.81 | IDH1 (0.41) | IDH1CRHR1P2RX7IL1BLRRK2 | |
| SCHEMBL30106881 | 0.78 | P2RX7 (0.35) | CRHR1P2RX7IL1BLRRK2BRD4 | |
| SCHEMBL30106871 | 0.77 | IDH1 (0.34) | IDH1P2RX7IL1B | |
| SCHEMBL14549691 | 0.77 | CRHR1 (0.37) | IDH1CRHR1LRRK2GRM2CNR1 | |
| SCHEMBL31010312 | 0.77 | IDH1 (0.36) | IDH1CRHR1P2RX7LRRK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | Grünenthal GmbH (DE) | 2024-06-04 | — | — | US | claimed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | claimed |
| US-11999699-B2 | Substituted pyrazole amides | Grünenthal GmbH (DE) | 2024-06-04 | — | — | US | disclosed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | SCN8A, SCN1A, SCN7A | IDH1 1865/4885CRHR1 2164/4885P2RX7 74/4885 |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | IDH1 1865/4885CRHR1 2164/4885P2RX7 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.