Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 10/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24757356 | 0.86 | SCN10A (0.48) | AKR1C3AKR1C2 | |
| SCHEMBL24758355 | 0.84 | SCN10A (0.48) | — | |
| SCHEMBL24906410 | 0.84 | SCN10A (0.53) | — | |
| SCHEMBL24758976 | 0.82 | AKR1C3 (0.40) | FLT1KDRAKR1C3AKR1C2NR3C1 | |
| SCHEMBL30141407 | 0.82 | AKR1C3 (0.46) | AKR1C3AKR1C2KMT2A | |
| SCHEMBL24757793 | 0.82 | AKR1C3 (0.46) | AKR1C3AKR1C2KMT2A | |
| SCHEMBL24906446 | 0.82 | AKR1C3 (0.40) | FLT1KDRAKR1C3AKR1C2NR3C1 | |
| SCHEMBL24906217 | 0.82 | SCN10A (0.43) | FLT1KDRAKR1C3AKR1C2 | |
| SCHEMBL24906428 | 0.82 | AKR1C3 (0.40) | FLT1KDRAKR1C3AKR1C2NR3C1 | |
| SCHEMBL30141357 | 0.82 | SCN10A (0.43) | FLT1KDRAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | Grünenthal GmbH (DE) | 2024-06-04 | — | — | US | disclosed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | SCN8A, SCN1A, SCN7A | POLB 4395/4885FLT1 2963/4885KDR 2752/4885 |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | POLB 4395/4885FLT1 2963/4885KDR 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.