Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | IL1B | P01584 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24757793 | 1.00 | AKR1C3 (0.46) | AKR1C3AKR1C2IL1BP2RX7RIPK1 | |
| SCHEMBL24758182 | 0.86 | SCN10A (0.51) | AKR1C3AKR1C2MEN1KMT2ANR1I2 | |
| SCHEMBL24757356 | 0.86 | SCN10A (0.48) | AKR1C3AKR1C2SCN10A | |
| SCHEMBL24906428 | 0.85 | AKR1C3 (0.40) | AKR1C3AKR1C2IL1BP2RX7RIPK1 | |
| SCHEMBL30141388 | 0.85 | AKR1C3 (0.40) | AKR1C3AKR1C2IL1BP2RX7RIPK1 | |
| SCHEMBL24906446 | 0.85 | AKR1C3 (0.40) | AKR1C3AKR1C2IL1BP2RX7KDM1A | |
| SCHEMBL24906460 | 0.84 | AKR1C3 (0.45) | AKR1C3AKR1C2P2RX7ALDH1A1MEN1 | |
| SCHEMBL24759017 | 0.83 | AKR1C3 (0.45) | AKR1C3AKR1C2ALDH1A1TP53PARP14 | |
| SCHEMBL30107027 | 0.83 | AKR1C3 (0.45) | AKR1C3AKR1C2ALDH1A1TP53PARP14 | |
| SCHEMBL30107034 | 0.82 | POLB (0.43) | AKR1C3AKR1C2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |