Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 11/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906217 | 1.00 | SCN10A (0.43) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL30141414 | 0.89 | AKR1C3 (0.35) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL24906460 | 0.89 | AKR1C3 (0.45) | SCN10AAKR1C3AKR1C2P2RX7NR1I2 | |
| SCHEMBL24757790 | 0.89 | AKR1C3 (0.35) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL30141517 | 0.85 | SCN10A (0.42) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL24758421 | 0.85 | SCN10A (0.42) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL24758348 | 0.83 | CNR1 (0.39) | AKR1C3AKR1C2P2RX7CNR1CNR2 | |
| SCHEMBL24758355 | 0.83 | SCN10A (0.48) | SCN10A | |
| SCHEMBL24758261 | 0.83 | P2RX7 (0.40) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL30141455 | 0.83 | P2RX7 (0.40) | SCN10AAKR1C3AKR1C2P2RX7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |