Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519343 | 1.00 | CYP11B1 (0.51) | CYP11B1CYP11B2MAP4K1HSP90AA1HSP90AB1 | |
| SCHEMBL21334716 | 0.90 | CYP11B1 (0.53) | CYP11B1CYP11B2MAP4K1HSP90AA1HSP90AB1 | |
| SCHEMBL20519101 | 0.90 | CYP11B1 (0.53) | CYP11B1CYP11B2MAP4K1HSP90AA1HSP90AB1 | |
| SCHEMBL29302494 | 0.75 | FFAR4 (0.49) | KMT2A | |
| SCHEMBL20519697 | 0.75 | MAP4K1 (0.67) | CYP11B1CYP11B2MAP4K1 | |
| SCHEMBL21334717 | 0.75 | MAP4K1 (0.67) | CYP11B1CYP11B2MAP4K1 | |
| SCHEMBL30107343 | 0.71 | CYP11B2 (0.53) | CYP11B1CYP11B2HSP90AA1HSP90AB1CYP19A1 | |
| SCHEMBL23535858 | 0.71 | CYP11B2 (0.58) | CYP11B1CYP11B2HSP90AA1HSP90AB1CYP19A1 | |
| SCHEMBL20524347 | 0.70 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1CYP19A1 | |
| SCHEMBL20519574 | 0.70 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |