Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FSHR | P23945 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20518879 | 1.00 | MAP4K1 (0.54) | MAP4K1MAPK1POLBTSHRFSHR | |
| SCHEMBL20519085 | 0.89 | MAP4K1 (0.65) | MAP4K1MAPK1POLBTSHRFSHR | |
| SCHEMBL30107453 | 0.89 | MAP4K1 (0.65) | MAP4K1MAPK1POLBTSHRFSHR | |
| SCHEMBL13327790 | 0.76 | POLB (0.55) | POLBP2RX7SMN1; SMN2MGLLPTGER1 | |
| SCHEMBL20519921 | 0.74 | L3MBTL1 (0.50) | MAP4K1 | |
| SCHEMBL30107289 | 0.74 | L3MBTL1 (0.50) | MAP4K1 | |
| SCHEMBL20520009 | 0.74 | GSK3B (0.47) | MAP4K1MAPK1PTGER1MAPKAPK2 | |
| SCHEMBL5143604 | 0.73 | DEGS1 (0.65) | POLBTSHRFSHRP2RX7ROCK2 | |
| SCHEMBL8129165 | 0.73 | POLB (0.51) | MAP4K1POLBTSHRFSHRSMN1; SMN2 | |
| SCHEMBL19194841 | 0.72 | MAP4K1 (0.49) | MAP4K1MAPK1POLBTSHRFSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |