Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | JUN | P05412 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.61 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5852180 | 1.00 | RAB9A (0.61) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL5852187 | 1.00 | RAB9A (0.61) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL8843775 | 0.85 | RAB9A (0.58) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL8843770 | 0.85 | RAB9A (0.58) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL1321367 | 0.84 | CYP1A1 (0.64) | MAPTMAPK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL1321365 | 0.84 | CYP1A1 (0.64) | MAPTMAPK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2184878 | 0.83 | KDM4E (0.67) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL16585159 | 0.83 | KDM4E (0.67) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL2184876 | 0.83 | KDM4E (0.67) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL22735131 | 0.82 | RAB9A (0.58) | RAB9AMAPTKDM4ENPC1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |