Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24047399 | 1.00 | MAPT (0.43) | MAPTFFAR1APPADORA2AGRM5 | |
| SCHEMBL3442581 | 0.82 | GRM5 (0.43) | MAPTFFAR1GRM5PTGES | |
| SCHEMBL14976213 | 0.80 | FFAR1 (0.42) | FFAR1APPADORA2AGRM5ADK | |
| SCHEMBL17714326 | 0.80 | ADK (0.44) | MAPTFFAR1APPADORA2AGRM5 | |
| SCHEMBL30166211 | 0.75 | SMN1; SMN2 (0.40) | MAPTFFAR1PIN1 | |
| SCHEMBL24053480 | 0.75 | SMN1; SMN2 (0.37) | MAPT | |
| SCHEMBL25274502 | 0.75 | SMN1; SMN2 (0.40) | MAPTFFAR1PIN1 | |
| SCHEMBL20576176 | 0.75 | APP (0.41) | MAPTAPPADORA2AGRM5ADK | |
| SCHEMBL13516538 | 0.74 | GRM5 (0.61) | MAPTFFAR1APPADORA2AGRM5 | |
| SCHEMBL3441623 | 0.73 | IKBKB (0.45) | MAPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153577-A1 | NEW MALONITRILE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-03-29 | — | — | EP | disclosed |
| CN-115551837-A | Novel malononitrile derivatives | 豪夫迈·罗氏有限公司 | 2022-12-30 | — | — | CN | disclosed |