Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519360 | 0.86 | UCHL1 (0.40) | UCHL1CYP11B2USP30KDM1ACHRM4 | |
| SCHEMBL30913149 | 0.82 | UCHL1 (0.48) | UCHL1CYP11B2USP30KDM1ACHRM4 | |
| SCHEMBL28812323 | 0.82 | UCHL1 (0.48) | UCHL1CYP11B2USP30KDM1ACHRM4 | |
| SCHEMBL30955311 | 0.80 | UCHL1 (0.39) | UCHL1CYP11B2USP30KDM1ACHRM4 | |
| SCHEMBL20517386 | 0.79 | GPR119 (0.38) | UCHL1CYP11B2USP30KDM1ACHRM4 | |
| SCHEMBL30955229 | 0.75 | ADORA1 (0.42) | UCHL1USP30GPR119HDAC1HDAC6 | |
| SCHEMBL25150812 | 0.74 | UCHL1 (0.44) | UCHL1CYP11B2USP30KDM1AGPR119 | |
| SCHEMBL28812299 | 0.73 | USP30 (0.39) | UCHL1CYP11B2USP30KDM1AGPR119 | |
| SCHEMBL29435672 | 0.71 | CHRM4 (0.43) | CYP11B2KDM1ACHRM4DRD2HTR7 | |
| SCHEMBL649859 | 0.71 | CHRM4 (0.43) | CYP11B2KDM1ACHRM4DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |