SCHEMBL30107979

SCHEMBL30107979

Nc1nc(-c2ccco2)cc(-n2ccc3cc(O)ccc32)n1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 3/20 0.45
CDK2 P24941 2/20 0.45
ADORA2A P29274 9/20 0.41
ADORA1 P30542 9/20 0.41
ADORA2B P29275 6/20 0.41
ROCK1 Q13464 5/20 0.40
ADORA3 P0DMS8 5/20 0.39
CSNK1A1 P48729 1/20 0.38
CSNK1D P48730 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30108045 0.83 ROCK1 (0.60) ADORA2AADORA1ADORA2BROCK1ADORA3
SCHEMBL30107959 0.77 KDM4E (0.44) ADORA2AADORA1ADORA2BADORA3CSNK1A1
SCHEMBL30107978 0.75 KDM4E (0.44) ADORA2AADORA1ADORA2BADORA3CSNK1A1
SCHEMBL30107952 0.73 ADORA2A (0.41) ADORA2AADORA1ADORA2BADORA3CSNK1A1
SCHEMBL1554000 0.72 MAPT (0.58) ADORA2AADORA1ADORA2BADORA3
SCHEMBL717572 0.71 MAPT (0.54) ADORA2AADORA1ADORA2BADORA3
SCHEMBL29876396 0.69 ADORA2A (0.44) ADORA2AADORA1ADORA2BADORA3
SCHEMBL6442516 0.69 USP2 (0.62) ADORA2AADORA1
SCHEMBL30488014 0.68 MAPT (0.53) ADORA2AADORA1ADORA2BADORA3
SCHEMBL29044796 0.68 MAPT (0.53) ADORA2AADORA1ADORA2BADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022203399-A1 ADENOSINE A2A RECEPTOR ANTAGONIST AND USE THEREOF 주식회사 스탠다임 2022-09-29 WO disclosed