Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28475108 | 0.87 | NR1H4 (0.58) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL27789995 | 0.84 | ALDH1A1 (0.55) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL167820 | 0.84 | RAB9A (0.58) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL11486934 | 0.82 | NR1H4 (0.53) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL7441613 | 0.81 | MAPT (0.50) | NR1H4HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL168593 | 0.81 | ALDH1A1 (0.56) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL161667 | 0.81 | ALDH1A1 (0.53) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL13963798 | 0.81 | MAPT (0.55) | NR1H4MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL27966314 | 0.81 | NR1H4 (0.52) | NR1H4HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL2176868 | 0.80 | RAB9A (0.53) | NR1H4MAPTALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653278-B2 | Isoform selective HDAC inhibitors | GEORGETOWN UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| EP-2049505-A2 | ISOFORM-SELECTIVE HDAC INHIBITORS | Georgetown University (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019025-A2 | ISOFORM-SELECTIVE HDAC INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | HDAC5, HDAC6, HDAC3 | NR1H4 1321/4885HDAC1 4/4885HDAC8 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.