Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684035 | 1.00 | TRPV1 (0.46) | TRPV1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL19556384 | 0.83 | P2RX7 (0.47) | TRPV1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL3246360 | 0.80 | TRPV1 (0.63) | TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5664894 | 0.74 | LATS1 (0.57) | TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5664378 | 0.74 | ROCK2 (0.61) | TRPV1 | |
| SCHEMBL5664368 | 0.74 | ROCK2 (0.61) | TRPV1 | |
| SCHEMBL5665109 | 0.74 | ROCK2 (0.61) | TRPV1 | |
| SCHEMBL30489416 | 0.73 | ROCK1 (0.49) | TRPV1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL20956352 | 0.73 | ROCK1 (0.49) | TRPV1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL30993431 | 0.73 | KDM4E (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204009-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-109641854-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-02-03 | — | — | CN | disclosed |